![]() Neurofibromatosis type 1 (von Recklinghausen disease NF1).Neurofibromatosis is an autosomal dominant condition with three distinct clinical subtypes: Patients often have learning and behavioural difficulties and seizures. Other clinical manifestations include retinal nodular hamartomas, and lesions in the kidneys (angiomyolipomas), heart (rhabdomyomas) and brain (subependymal giant cell astrocytomas, cortical tubers). Multiple and randomly distributed dental enamel pits.Shagreen patch (a connective tissue naevus).Non- traumatic ungual or periungual fibromas.Facial angiofibromas or forehead plaque. ![]() Skin manifestations of tuberous sclerosis include: Note that there is no single diagnostic feature, and none are specific for TSC. Major features have higher specificity for TSC than minor features. Diagnosis of TSC is based on major and minor clinical criteria. Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome caused by mutations in the tumour suppressor genes, TSC1 and TSC2. Neurocutaneous disorders are a group of congenital multisystem diseases that result in the growth of tumours in the brain, spinal cord, skin and other organs. Neuropathic itch is also discussed in this topic. ![]() Neuropsychiatric disorders and addictions.Neurological diseases associated with skin signs include: ![]()
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